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Allostery The picture that emerges from a gallery of different ArsR family structures is that the sensing sites are widely distributed throughout this simple molecular scaffold, which in turns triggers a change in structure and/or conformational dynamics that inhibits DNA binding by several orders of magnitude ( G c +36 kcal/mol
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(1) In patients with correctible or temporary causes of vitamin B12 deficiency the benefit of continued long-term use following correction of vitamin B12 deficiency and underlying disease has not been established
By age 60, that figure drops to around 80 ng/mL, a reduction of approximately 60%
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Such diseases often arise from impaired vascular function, leading to severe complications such as myocardial infarction and cerebrovascular accidents (Prakash Babu et al., 2019
